The Gadani Lab Translational Neuroimmunology Research at Pitt

Publications

Highlighted

Spatial Transcriptomics of Meningeal Inflammation Reveals Inflammatory Gene Signatures in Adjacent Brain Parenchyma
Spatial Transcriptomics of Meningeal Inflammation Reveals Inflammatory Gene Signatures in Adjacent Brain Parenchyma
Sachin P. Gadani, Saumitra Singh, Sophia Kim, Jingwen Hu, Matthew D. Smith, Peter A. Calabresi, Pavan Bhargava
openRxiv  ·  06 Jun 2023  ·  doi:10.1101/2023.06.02.543421

All

2025

Bile acid metabolites predict multiple sclerosis progression and supplementation is safe in progressive disease
Dimitrios C. Ladakis, Kimystian L. Harrison, Matthew D. Smith, Krista Solem, Sachin Gadani, …, Kathryn C. Fitzgerald, Elias S. Sotirchos, Shiv Saidha, Peter A. Calabresi, Pavan Bhargava
Med  ·  01 Mar 2025  ·  doi:10.1016/j.medj.2024.09.011
NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway
Alexander J. Gill, Matthew D. Smith, Danny Galleguillos, Thomas Garton, Jackson W. Mace, …, Giuliana Sardi Rogines, Arihant Singh, Annatje Clark, Peter A. Calabresi, Marjan Gharagozloo
Journal of Neuroinflammation  ·  28 Jan 2025  ·  doi:10.1186/s12974-025-03339-0

2024

Spatial transcriptomics of meningeal inflammation reveals inflammatory gene signatures in adjacent brain parenchyma
Sachin P Gadani, Saumitra Singh, Sophia Kim, Jingwen Hu, Matthew D Smith, Peter A Calabresi, Pavan Bhargava
eLife  ·  30 Oct 2024  ·  doi:10.7554/eLife.88414.4
Bile acid metabolites predict multiple sclerosis progression and supplementation is safe in progressive disease
Dimitrios C. Ladakis, Kimystian L. Harrison, Matthew D. Smith, Krista Solem, Sachin Gadani, …, Kathryn C. Fitzgerald, Elias S. Sotirchos, Shiv Saidha, Peter A. Calabresi, Pavan Bhargava
openRxiv  ·  21 Jan 2024  ·  doi:10.1101/2024.01.17.24301393

2023

Pre-existing neurological conditions and COVID-19 co-infection: Data from systematic reviews, meta-analyses, and scoping reviews
Abhilasha P. Boruah, Kiran T. Thakur, Sachin P. Gadani, Kavita U. Kothari, Mashina Chomba, …, Katrin Seeher, Tom Solomon, Andrea S. Winkler, Greta K. Wood, Nicoline Schiess
Journal of the Neurological Sciences  ·  01 Dec 2023  ·  doi:10.1016/j.jns.2023.120858
Serum macrophage migration inhibitory factor levels predict brain atrophy in people with primary progressive multiple sclerosis
Dimitrios C Ladakis, Maria I Reyes-Mantilla, Sachin P Gadani, Jackson W Mace, Susana C Dominguez-Penuela, …, Matthew D Smith, Pavan Bhargava, Robert J Fox, Shiv Saidha, Peter A Calabresi
Multiple Sclerosis Journal  ·  20 Nov 2023  ·  doi:10.1177/13524585231213164
The calvaria stands alone: Unique aspects of the skull bone marrow-meninges border
Sachin P. Gadani, Peter A. Calabresi
Cell  ·  01 Aug 2023  ·  doi:10.1016/j.cell.2023.07.025
Spatial Transcriptomics of Meningeal Inflammation Reveals Inflammatory Gene Signatures in Adjacent Brain Parenchyma
Sachin P. Gadani, Saumitra Singh, Sophia Kim, Jingwen Hu, Matthew D. Smith, Peter A. Calabresi, Pavan Bhargava
openRxiv  ·  06 Jun 2023  ·  doi:10.1101/2023.06.02.543421
Emerging imaging and liquid biomarkers in multiple sclerosis
Alexander J. Gill, Emily M. Schorr, Sachin P. Gadani, Peter A. Calabresi
European Journal of Immunology  ·  28 May 2023  ·  doi:10.1002/eji.202250228

2022

Successful Thrombectomy for Large Vessel Occlusion after Emergent Transoceanic Patient Transport: An International Hub and Spoke Collaboration
Sachin P. Gadani, Francene Gayle, Phillip Jones, Phillipe Gailloud, Roland Faigle, Victor C. Urrutia
Cerebrovascular Diseases  ·  04 Oct 2022  ·  doi:10.1159/000526295
Acute Necrotizing Encephalitis as an Early Manifestation of COVID-19
Sachin Gadani, Adam Cohen
Cureus  ·  12 Aug 2022  ·  doi:10.7759/cureus.27928
DICAM, a molecular passport for T H 17 cell entry into the brain
Sachin P. Gadani, Michael D. Kornberg
Science Translational Medicine  ·  05 Jan 2022  ·  doi:10.1126/scitranslmed.abm7204

2021

Neurosyphilis, MOGAD or both? A case of meningoencephalomyelitis associated with MOG-IgG seropositivity in a patient with syphilis
Julie C. Gudenkauf, Sachin P. Gadani, Justin C. McArthur, Elias S. Sotirchos
Neuroimmunology Reports  ·  01 Dec 2021  ·  doi:10.1016/j.nerep.2021.100003
Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy
Sachin P. Gadani, Maria Reyes-Mantilla, Larissa Jank, Samantha Harris, Morgan Douglas, Matthew D. Smith, Peter A. Calabresi, Ellen M. Mowry, Kathryn C. Fitzgerald, Pavan Bhargava
EBioMedicine  ·  01 Nov 2021  ·  doi:10.1016/j.ebiom.2021.103636

2019

Granulomatosis with Polyangiitis Manifesting as a Symptomatic Sellar Mass in a Young Woman
Sachin P Gadani, Rohini Nadgir, Annika Windon, Lisa Rooper, Fahid Alghanim
Cureus  ·  02 Oct 2019  ·  doi:10.7759/cureus.5823

2017

How and why do T cells and their derived cytokines affect the injured and healthy brain?
Anthony J. Filiano, Sachin P. Gadani, Jonathan Kipnis
Nature Reviews Neuroscience  ·  27 Apr 2017  ·  doi:10.1038/nrn.2017.39

2016

Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury
Sachin P. Gadani, Igor Smirnov, Ashtyn T. Wiltbank, Christopher C. Overall, Jonathan Kipnis
Journal of Experimental Medicine  ·  19 Dec 2016  ·  doi:10.1084/jem.20161982
Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
Anthony J. Filiano, Yang Xu, Nicholas J. Tustison, Rachel L. Marsh, Wendy Baker, …, Kevin S. Lee, Michael M. Scott, Mark P. Beenhakker, Vladimir Litvak, Jonathan Kipnis
Nature  ·  01 Jul 2016  ·  doi:10.1038/nature18626
Shedding light on IL-33 in the eye
Sachin P. Gadani, Jonathan Kipnis
Journal of Experimental Medicine  ·  08 Feb 2016  ·  doi:10.1084/jem.2132insight2
Natural killers in the brain's nursery
Sachin P Gadani, Jonathan Kipnis
Nature Neuroscience  ·  27 Jan 2016  ·  doi:10.1038/nn.4227

2015

Interactions of innate and adaptive immunity in brain development and function
Anthony J. Filiano, Sachin P. Gadani, Jonathan Kipnis
Brain Research  ·  01 Aug 2015  ·  doi:10.1016/j.brainres.2014.07.050
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4
James T. Walsh, Sven Hendrix, Francesco Boato, Igor Smirnov, Jingjing Zheng, …, Ralf Gold, Thirumala-Devi Kanneganti, Robert Nitsch, Frauke Zipp, Jonathan Kipnis
Journal of Clinical Investigation  ·  04 May 2015  ·  doi:10.1172/JCI82458
Brainless immunity no more
Sachin P Gadani, Jonathan Kipnis
Nature Immunology  ·  21 Apr 2015  ·  doi:10.1038/ni.3145
The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury
Sachin P. Gadani, James T. Walsh, Igor Smirnov, Jingjing Zheng, Jonathan Kipnis
Neuron  ·  01 Feb 2015  ·  doi:10.1016/j.neuron.2015.01.013
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4
James T. Walsh, Sven Hendrix, Francesco Boato, Igor Smirnov, Jingjing Zheng, …, Ralf Gold, Thirumala-Devi Kanneganti, Robert Nitsch, Frauke Zipp, Jonathan Kipnis
Journal of Clinical Investigation  ·  20 Jan 2015  ·  doi:10.1172/JCI76210

2014

Chemokine-induced trafficking of T cells into the meninges through the brain "gates"
Antoine Louveau, Sachin Gadani, Tajie Harris, Jonathan Kipnis
Journal of Neuroimmunology  ·  01 Oct 2014  ·  doi:10.1016/j.jneuroim.2014.08.543

2012

IL-4 in the Brain: A Cytokine To Remember
Sachin P Gadani, James C Cronk, Geoffrey T Norris, Jonathan Kipnis
The Journal of Immunology  ·  01 Nov 2012  ·  doi:10.4049/jimmunol.1202246
Pro-cognitive properties of T cells
Jonathan Kipnis, Sachin Gadani, Noël C. Derecki
Nature Reviews Immunology  ·  20 Aug 2012  ·  doi:10.1038/nri3280

2011

Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions
J D Lathia, M Hitomi, J Gallagher, S P Gadani, J Adkins, …, D Corbeil, A Chenn, A B Hjelmeland, D M Park, J N Rich
Cell Death & Disease  ·  01 Sep 2011  ·  doi:10.1038/cddis.2011.80
SSR markers developed for genetic mapping in flax (Linum usitatissimum L.)
Chris Cullis, Bickel, Gadani, Lukacs
Research and Reports in Biology  ·  01 Mar 2011  ·  doi:10.2147/RRB.S16091